PRF · Platelet-Rich Fibrin
A blood-derived platelet preparation with a fibrin component. PRF and PRP differ in preparation and composition; the choice follows the intended use rather than one being automatically better.
Your care, step by step.
Define the aim
Assess the area and explain why PRF is being considered.
Collect & prepare
Obtain a blood sample and prepare the agreed PRF formulation.
Apply & recover
Follow the application plan and specific recovery guidance.
Review together
Discuss the response and whether any next step is justified.
What to plan for
The preparation and application are specific to the plan. Evidence for facial rejuvenation remains variable; discuss the expected benefit, limitations and review schedule.
The sequence, session count and intervals are agreed individually. This is a pathway, not a fixed calendar.
An informed choice.
What the evidence can tell you — and where its limits matter.
Sources checkedEvidence & expectations
A 2025 systematic review considered PRP and PRF across facial-ageing outcomes. Findings differed by outcome and preparation. It does not establish PRF as superior to PRP or as a substitute for a volume-replacing filler.[1]
Preparation & recovery
Clarify whether injectable PRF or another formulation is proposed and what the treatment is meant to change. The preparation, application and review schedule need to match that specific aim.[1]
Risks & limitations
Limited study sizes and follow-up leave uncertainty about uncommon events and durability. Ask about discomfort, local injection effects and how the team would assess an unexpected reaction.[1]
Compare your options
Compare composition and clinical purpose rather than a “more natural” label. PRP is a relevant comparison, but results from one blood-derived preparation cannot simply be transferred to another.[1]
Different approaches to discuss
These links explain different targets. They are not personalised recommendations.
PRP · Platelet-Rich PlasmaHyaluronic acidSources & further reading
- Systematic reviewPRP and PRF in facial rejuvenation: systematic reviewQin et al. · Annals of Plastic Surgery · 2025
How we use evidence
A controlled trial compares interventions in defined groups; an uncontrolled cohort cannot, alone, establish causality. A review depends on the quality of its included studies. We distinguish these sources from manufacturer information and identify when findings do not directly apply to the platform or protocol.
The date records when sources were checked for this guide. It is not a statement of individual clinical review, product authorisation or confirmation of the clinic’s available configuration.
This guide supports a conversation with your clinician. It does not determine your suitability or replace individual aftercare instructions.
Start with your priorities.
Discuss suitability, alternatives, expected recovery and costs at your medical assessment.